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ea0029p1632 | Thyroid (non-cancer) | ICEECE2012

Late manifestation of subclinical hyperthyroidism after goitrogenesis in an index patient with a N 670 S TSH receptor germline mutation causing familial non-autoimmune autosomal dominant hyperthyroidism (FNAH)

Paschke S. , Oezerden M. , Schaarschmidt J. , Jaeschke H. , Huth S. , Eszlinger M. , Meller J. , Paschke R.

In the 27 families with FNAH the onset of hyperthyroidism varies from 18 months to 60 years. Also the manifestation of goiters is variable in these families.A 74 year old women first presented at the age of 69 years in 9/2006 with tachyarrythmia and hypertension. After the initial treatment of her hypertension and oral anticoagulation for her intermittant atrialfibrilation 3/2007 a thyroid workup revealed a suppressed TSH of 0.029 (normal< 0.4 mU/l) ...

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ea0049oc4.2 | Thyroid Disease 1 | ECE2017

Inducible thyrocyte-specific Gs alpha-deficient mice as a novel model for hypothyroidism

Patyra Konrad , Jaeschke Holger , Undeutsch Henriette , Lof Christoffer , Ruohonen Suvi , Jannari Meeri , Chen Min , Weinstein Lee S. , Paschke Ralf , Toppari Jorma , Kero Jukka

The thyroid gland produces thyroid hormones, which are essential regulators of growth, development and metabolism of the body and is mainly regulated by the thyroid stimulating hormone (TSH)/TSH receptor (TSHR) interplay. The TSHR couples to all four G protein families in vitro but only for the Gs and Gq signaling cascade a role has been identified in vivo. To gain further insights into the complex signaling networks mediated by G proteins in the thyroid, we generated...

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Endocrine Abstracts

Late manifestation of subclinical hyperthyroidism after goitrogenesis in an index patient with a N 670 S TSH receptor germline mutation causing familial non-autoimmune autosomal dominant hyperthyroidism (FNAH)

Inducible thyrocyte-specific Gs alpha-deficient mice as a novel model for hypothyroidism

BiosciAbstracts